Silvalab

Understanding and Treating Memory

publications

Research Articles

Czajkowski, R, Jayaprakash, B, Wiltgen, B, Rogerson, T, Karlsson, MG, Barth, A, Trachtenberg, J, and Silva, AJ. Encoding and storage of spatial information in the retrosplenial cortex. PNAS 2014 111 (23) 8661-8666. PMID: 24912150 (PDF)

Landreth, A. and Silva, A.J. The Need for Research Maps to Navigate Published Work and Inform Experiment Planning. Neuron 2013 79 411-415
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Xiaoning Han, Michael Chen, Fushun Wang, Guo-Feng Tian, Martha Windrem, Su Wang, Steven Shanz, Qiwu Xu, Nancy Ann Oberhein, Lane Bekar, Alcino J. Silva, Takahiro Takano, Steven A. Goldman, Maiken Nedergaard. Human glia progenitors enhance synaptic plasticity and learning in adult mice. Cell Stem Cell
2013 Mar 7;12(3):342-53. PMID: 23472873

Zhou, M, Li, W, Huang, S, Song, J, Kim, J Tian, X, Kang, E Sano, Y, Liu, C, Balaji, J, Wu, S, Zhou, Y, Zhou, Y, Parivash, S, Ehninger, D, He, L. Song, H, 3, Ming, G, Silva AJ mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown Specifically in Adult-Born Dentate Granule Neurons. Neuron 77, 647–654, 2013
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Caccamo A, Magrì A, Medina DX, Wisely EV, López-Aranda MF, Silva AJ, Oddo S. mTor regulates tau phosphorylation and degradation: implications for alzheimer's disease and other tauopathies. Aging Cell. 2013 Feb 20. doi: 10.1111/acel.12057. PMID: 23425014

Karlsgodt K, , Rosser T, Lutkenhoff ES, Cannon TD, Silva AJ, and Bearden CE (2012). Alterations in white matter microstructure in neurofibromatosis-1. PloS one 7(10): e47854. PMID: 23094098

Gdalyahu, A., Tring, E., Polack, P., Gruver, R., Golshani, P., Fanselow, M. S., Silva, Trachtenberg, J. T. (2012) Associative Fear Learning Enhances Sparse Network Coding in Primary Sensory Cortex. Neuron, 75, 121-132. PMID: 22794266

Cho, J., R. Bhatt, Y. Elgersma, and A.J. Silva, alpha-Calcium Calmodulin Kinase II Modulates the Temporal Structure of Hippocampal Bursting Patterns. PloS one, 2012. 7(2): p. e31649. PMID: 22363696

Halt, A.R., R.F. Dallapiazza, Y. Zhou, I.S. Stein, H. Qian, S. Juntti, S. Wojcik, N. Brose, A.J. Silva, and J.W. Hell, CaMKII binding to GluN2B is critical during memory consolidation. The EMBO journal, 2012. 31(5): p. 1203-16. PMID:22234183

Ehninger, D., Y. Sano, P.J. de Vries, K. Dies, D. Franz, D.H. Geschwind, M. Kaur, Y.S. Lee, W. Li, J.K. Lowe, J.A. Nakagawa, M. Sahin, K. Smith, V. Whittemore, and A.J. Silva, Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice. Molecular psychiatry, 2012. 17(1): p. 62-70. PMID: 21079609

Ehninger, D. and A.J. Silva, Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis. Behavior genetics, 2011. 41(3): p. 357-63.

Kye, M.J., P. Neveu, Y.S. Lee, M. Zhou, J.A. Steen, M. Sahin, K.S. Kosik, and A.J. Silva, NMDA mediated contextual conditioning changes miRNA expression. PloS one, 2011. 6(9): p. e24682.

Shilyansky C, Karlsgodt KH, Cummings DM, Sidiropoulou K, Hardt M, James AS, Ehninger D, Bearden CE, Poirazi P, Jentsch JD, Cannon TD, Levine MS, Silva AJ. Neurofibromin regulates corticostriatal inhibitory networks during working memory performance. Proc Natl Acad Sci U S A. 2010 Jul 12. PMID: 20624961
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Wiltgen, B.J., M. Zhou, Y. Cai, J. Balaji, M.G. Karlsson, S.N. Parivash, W. Li, and A.J. Silva, The Hippocampus Plays a Selective Role in the Retrieval of Detailed Contextual Memories. Curr Biol, 2010. 20(15): p. 1336-1344. PMID: 20637623
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Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci. 2010 Apr;13(4):423-30. PMID: 20228804.
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Ehninger, D., Y. Sano, P.J. de Vries, K. Dies, D. Franz, D.H. Geschwind, M. Kaur, Y.S. Lee, W. Li, J.K. Lowe, J.A. Nakagawa, M. Sahin, K. Smith, V. Whittemore, and A.J. Silva, Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice. Mol Psychiatry, 2010.
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Ehninger, D. and A.J. Silva, Increased Levels of Anxiety-related Behaviors in a Tsc2 Dominant Negative Transgenic Mouse Model of Tuberous Sclerosis. Behav Genet, 2010.


Zhou, Y., J. Won, et al. (2009). "CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala." Nat Neurosci.
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Cui, Y, Costa, RM, Murphy, GG, Elgersma, Y, Zhu, Y, Gutmann, DH, Parada, LF, Mody, I, and Silva, AJ, Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell 2008 135(3) pp. 549 – 560. (
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Krab, L.C., A. de Goede-Bolder, F.K. Aarsen, S.M. Pluijm, M.J. Bouman, J.N. van der Geest, M. Lequin, C.E. Catsman, W.F. Arts, S.A. Kushner, A.J. Silva, C.I. de Zeeuw, H.A. Moll, and Y. Elgersma, Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial. Jama, 2008. 300(3): p. 287-94. (
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Ehninger, D., S. Han, C. Shilyansky, Y. Zhou, W. Li, D.J. Kwiatkowski, V. Ramesh, and A.J. Silva, Reversal of learning deficits in a Tsc2(+/-) mouse model of tuberous sclerosis. Nat Med, 2008.(
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Matynia, A., S.G. Anagnostaras, B.J. Wiltgen, M. Lacuesta, M.S. Fanselow, and A.J. Silva, A high through-put reverse genetic screen identifies two genes involved in remote memory in mice. PLoS ONE, 2008. 3(5): p. e2121.(
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Hojjati MR, van Woerden GM, Tyler WJ, Giese KP, Silva AJ, Pozzo-Miller L, Elgersma Y. Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses. Nat Neurosci 2007; 10(9): 1125-7.


Ishizuka, K., Chen, J., Taya, S., Li, W., Millar, J.K., Xu, Y., Clapcote, S.J., Hookway, C., Morita, M., Kamiya, A., et al. (2007). Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice. Molecular psychiatry 12, 897-899.


Li, W., Zhou, Y., Jentsch, J.D., Brown, R.A., Tian, X., Ehninger, D., Hennah, W., Peltonen, L., Lonnqvist, J., Huttunen, M.O Kaprio, J., Trachtenberg, J. T., Silva, A. J.*, Cannon, T. D.2007). Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci U S A 104, 18280-18285. *corresponding author.(
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Zhou, Y., Takahashi, E., Li, W., Halt, A., Wiltgen, B., Ehninger, D., Li, G.D., Hell, J.W., Kennedy, M.B., and Silva, A.J. (2007). Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning. J Neurosci 27, 13843-13853.(
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Jin-Hee Han, Steven A. Kushner, Adelaide P. Yiu, Christy A. Cole, Anna Matynia, Robert A. Brown, Rachael Neve, John F. Guzowski, Alcino J. Silva, Sheena A. Josselyn. Neuronal competition and selection during memory formation. Science 2007, 31: 457-460(
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Wiltgen, BJ. Silva, AJ. Memory for context becomes less specific with time Learning and Memory, 2007, 14: 313-317 (
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Uchida, S., S. Sakai, T. Furuichi, H. Hosoda, K. Toyota, T. Ishii, A. Kitamoto, M. Sekine, K. Koike, S. Masushige, G. Murphy, A.J. Silva, and S. Kida, Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain. Genes Brain Behav, 2006. 5(1): p. 96-106.


Paul W. Frankland, Hoi-Ki Ding, Eiki Takahashi, Akinobu Suzuki, Satoshi Kida and Alcino J. Silva, Stability of recent and remote contextual fear memory. Learning and Memory, 2006, 13: 451-457.(
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Murphy, G., Shah, V.,. Hell, J.W., Silva, A.J. Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates. Am J Geriatr Psychiatry. 2006 Dec;14(12):1012-21. (
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Murphy, G., Shah, V.,. Hell, J.W., Silva, A.J. Investigation of age-related cognitive decline using mice as a model system: behavioral correlates. Am J Geriatr Psychiatry. 2006 Dec;14(12):1004-11.(
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Chen, A.P., M. Ohno, K.P. Giese, R. Kuhn, R.L. Chen, and A.J. Silva, Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory. J Neurosci Res, 2006. 83(1): p. 28-38.(
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Ohno, M., W. Tseng, A.J. Silva, and J.F. Disterhoft, Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice. Learn Mem, 2005. 12(3): p. 211-5.


Kushner, S.A., Y. Elgersma, G.G. Murphy, D. Jaarsma, G.M. van Woerden, M.R. Hojjati, Y. Cui, J.C. LeBoutillier, D.F. Marrone, E.S. Choi, C.I. De Zeeuw, T.L. Petit, L. Pozzo-Miller, and A.J. Silva, Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway. J Neurosci, 2005. 25(42): p. 9721-34. (
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Li, W., Y. Cui, S.A. Kushner, R.A. Brown, J.D. Jentsch, P.W. Frankland, T.D. Cannon, and A.J. Silva, The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol, 2005. 15(21): p. 1961-7. (
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Ohno, M., W. Tseng, A.J. Silva, and J.F. Disterhoft, Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice. Learn Mem, 2005. 12(3): p. 211-5.


Zeitz, K.P., K.P. Giese, A.J. Silva, and A.I. Basbaum, The contribution of autophosphorylated alpha-calcium-calmodulin kinase II to injury-induced persistent pain. Neuroscience, 2004. 128(4): p. 889-98.


Frankland, P.W., Josselyn, S.A., Anagnostaras, S.G., Kogan, J.H., Takahashi, E., and Silva, A.J. (2004). Consolidation of CS and US representations in associative fear conditioning. Hippocampus 14, 557-569. (
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Murphy GG, Fedorov NB, Giese KP, Ohno M, Friedman E, Chen R, Silva AJ. Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice. Curr Biol. 2004 Nov 9;14(21):1907-15.(
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Josselyn, S., Kida, S., and Silva, A. (2004). Inducible Repression of CREB Function Disrupts Amygdala-Dependent Memory. Neurobiology of Learning and Memory 82, 159-163. (
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Suzuki, A., Josselyn, S.A., Frankland, P.W., Masushige, S., Silva, A.J., and Kida, S. (2004). Memory reconsolidation and extinction have distinct temporal and biochemical signatures. J Neurosci 24, 4787-4795.


Frankland, P., B. Bontempi, L. Talton, L. Kaczmarek, and A. Silva, The anterior cingulate cortex is critical for remote contextual fear memory, 2004. Science 304, 881-3.(
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Frankland, P.W., Y. Wang, B. Rosner, T. Shimizu, B.W. Balleine, E.M. Dykens, E.M. Ornitz, and A.J. Silva, Sensorimotor gating abnormalities in young males with Fragile X syndrome and Fmr1-knockout mice. Molecular Psychiatry, 2004, 9, 417-425.(
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Anagnostaras, S.G., G.G. Murphy, S.E. Hamilton, S.L. Mitchell, N.P. Rahnama, N.M. Nathanson, and A.J. Silva, Selective cognitive dysfunction in acetylcholine M(1) muscarinic receptor mutant mice. Nat Neurosci, 2003. 6(1): p. 51-58 (
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Dhaka, A., R. Costa, H. Hu, D. Irvin, A. Patel, H. Kornblum, A. Silva, T. O'Dell, and J. Colicelli, The Ras Effector Rin1 Modulates the Formation of Aversive Memories. Journal of Neuroscience, 2003, 23(3):748-57.


Taha, S., J. Hanover, A. Silva, and M.P. Stryker, Autophosphorylation of alpha CaMKII is required for ocular dominance plasticity. Neuron, 2002. 36(3): p. 483-491.


Elgersma, Y., N. Fedorov, S. Ikonen, E. Choi, M. Elgersma, O. Carvalho, K. Giese, and A. Silva, Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity and learning. Neuron, 2002. 36(3): p. 493-505.(
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Ohno, M., P. Frankland, and A. Silva, Pharmacogenetic inducible approach to the study of NMDA/aCaMKII signaling in synaptic plasticity. Current Biology, 2002. 12(8): p. 654-656.
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Givogri, M.I., R.M. Costa, V. Schonmann, A.J. Silva, A.T. Campagnoni, and E.R. Bongarzone, Central nervous system myelination in mice with deficient expression of Notch1 receptor. Journal of Neuroscience Research, 2002. 67(3): p. 309-320.


Kida, S., S. Josselyn, S. Ortiz, J. Kogan, I. Chevere, S. Masushige, and A. Silva, CREB required for the stability of new and reactivated fear memories. Nature Neuroscience, 2002. 5: p.:348-55.
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Costa, R.M., N.B. Federov, J.H. Kogan, G.G. Murphy, J. Stern, M. Ohno, R. Kucherlapati, T. Jacks, and A.J. Silva, Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature, 2002. 415(6871): p. 526-30.
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Ohno, M., P.W. Frankland, A.P. Chen, R.M. Costa, and A.J. Silva, Inducible, pharmacogenetic approaches to the study of learning and memory. Nature Neuroscience, 4, 1238-43, 2001.
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Pham, T.A., J.L. Rubenstein, A.J. Silva, D.R. Storm, and M.P. Stryker, The cre/creb pathway is transiently expressed in thalamic circuit development and contributes to refinement of retinogeniculate axons. Neuron, 2001. 31(3): p. 409-20.


Giese, K., E. Friedman, J.-P. Telliez, N. Fedorov, W. Wines, L. Feig, and A.J. Silva, Hippocampus-dependent learning and memory is impaired in mice lacking the ras-guanine-nucleotide releasing factor 1(ras-GRF-1). Neuropharmacology, 2001. 41(16): p. 791-800.
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Frankland, P., C. O'Brien, M. Ohno, A. Kirkwood, and A. Silva, CaMKII-Dependent Plasticity in the neocortex is required for remote memory. Nature, 2001. 411: p. 309-13.
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Costa, R.M., T. Yang, D.P. Huynh, S.M. Pulst, D.H. Viskochil, A.J. Silva, and C.I. Brannan, Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1. [Comment In: Nat Genet. 2001 Apr;27(4):354-5 UI: 21175732]. Nature Genetics, 2001. 27(4): p. 399-405.
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Pandey, S., N. Mittal, and A. Silva, Blockade of cyclic AMP-responsive-element DNA binding in the brain of CREB alpha/delta mutant mice. Neuroreport, 2000. 3(11): p. 2577-80.

Ferguson, G.D., S.G. Anagnostaras, A.J. Silva, and H.R. Herschman, Deficits in memory and motor performance in synaptotagmin IV mutant mice. Proceedings of the National Academy of Sciences of the United States of America, 2000. 97(10): p. 5598-603.
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Falls, W.A., J.H. Kogan, A.J. Silva, J.F. Willott, S. Carlson, and J.G. Turner, Fear-potentiated startle, but not prepulse inhibition of startle, is impaired in CREBalphadelta-/- mutant mice. Behav Neurosci, 2000. 114(5): p. 998-1004.


Glazewski, S., K. Giese, A. Silva, and K. Fox, The role of alpha- CaMKII autophosphorylation in neocortical experience-dependent plasticity. Nature Neuroscience, 2000. 3: p. 911-918.


Kogan, J.H., P.W. Frankland, and A.J. Silva, Long-term memory underlying hippocampus-dependent social recognition in mice. Hippocampus, 2000. 10(1): p. 47-56.


Anagnostaras, S.G., S.A. Josselyn, P.W. Frankland, and A.J. Silva, Computer-assisted behavioral assessment of Pavlovian fear conditioning in mice. Learn Mem, 2000. 7(1): p. 58-72.


Glazewski, S., A.L. Barth, H. Wallace, M. McKenna, A. Silva, and K. Fox, Impaired experience-dependent plasticity in barrel cortex of mice lacking the alpha and delta isoforms of CREB. Cereb Cortex, 1999. 9(3): p. 249-56.


Narisawa-Saito, M., A.J. Silva, T. Yamaguchi, T. Hayashi, T. Yamamoto, and T. Nawa, Fyn Growth factor-mediated fyn signaling regulates alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons. Proc Natl Acad Sci U S A, 1999. 96(5): p. 2461-6.


Cho, Y.H., E. Friedman, and A.J. Silva, Ibotenate lesions of the hippocampus impair spatial learning but not contextual fear conditioning in mice. Behavioural Brain Research, 1999. 98(1): p. 77-87.
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Giese, K.P., J.F. Storm, D. Reuter, N.B. Fedorov, L.-R. Shao, T. Leicher, O. Pongs, and A.J. Silva, Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvß1.1-deficient mice with impaired learning. Learning and Memory, 1998. 5: p. 257-273.


Frankland, P.W., V. Cestari, R. Filipkowski, R.J. McDonald, and A.J. Silva, The dorsal hippocampus is essential for context discrimination but not for contextual conditioning. Behavioral Neuroscience, 1998. 112(4): p. 863-874.


Cho, Y.H., K.P. Giese, H. Tanila, A.J. Silva, and H. Eichenbaum, Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta- mice. Science, 1998. 279(5352): p. 867-9.


Giese, K.P., N.B. Fedorov, R.K. Filipkowski, and A.J. Silva, Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science, 1998. 279(5352): p. 870-3.
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Kirkwood, A., A. Silva, and M.F. Bear, Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice. Proc Natl Acad Sci U S A, 1997. 94(7): p. 3380-3.
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Silva, A.J., P.W. Frankland, Z. Marowitz, E. Friedman, G. Lazlo, D. Cioffi, T. Jacks, and R. Bourtchuladze, A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nat Genet, 1997. 15(3): p. 281-4.


Kogan, J.H., P.W. Frankland, J.A. Blendy, J. Coblentz, Z. Marowitz, G. Schutz, and A.J. Silva, Spaced training induces normal long-term memory in CREB mutant mice. Curr Biol, 1997. 7(1): p. 1-11.


Silva, A.J., T.W. Rosahl, P.F. Chapman, Z. Marowitz, E. Friedman, P.W. Frankland, V. Cestari, D. Cioffi, T.C. Südhof, and R. Bourtchuladze, Impaired learning in mice with abnormal short-lived plasticity. Current Biology, 1996. 6(11): p. 1509-18.


Gordon, J.A., D. Cioffi, A.J. Silva, and M.P. Stryker, Deficient plasticity in the primary visual cortex of alpha-calcium/calmodulin-dependent protein kinase II mutant mice. Neuron, 1996. 17(3): p. 491-9.


Glazewski, S., C.M. Chen, A. Silva, and K. Fox, Requirement for alpha-CaMKII in experience-dependent plasticity of the barrel cortex. Science, 1996. 272(5260): p. 421-3.


Waxham, M.N., J.C. Grotta, A.J. Silva, R. Strong, and J. Aronowski, Ischemia-induced neuronal damage: a role for calcium/calmodulin-dependent protein kinase II. Journal of Cerebral Blood Flow and Metabolism, 1996. 16(1): p. 1-6.


Butler, L.S., A.J. Silva, A. Abeliovich, Y. Watanabe, S. Tonegawa, and J.O. McNamara, Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation. Proceedings of the National Academy of Sciences of the United States of America, 1995. 92(15): p. 6852-5.


Chapman, P.F., B.G. Frenguelli, A. Smith, C.M. Chen, and A.J. Silva, The alpha-Ca2+/calmodulin kinase II: a bidirectional modulator of presynaptic plasticity. Neuron, 1995. 14(3): p. 591-7.


Bourtchuladze, R., B. Frenguelli, J. Blendy, D. Cioffi, G. Schutz, and A.J. Silva, Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell, 1994. 79(1): p. 59-68.


Silva, A.J., K. Ward, and R. White, Mosaic methylation in clonal tissue. Dev Biol, 1993. 156(2): p. 391-8.


Abeliovich, A., C. Chen, Y. Goda, A.J. Silva, C.F. Stevens, and S. Tonegawa, Modified hippocampal long-term potentiation in PKC gamma-mutant mice. Cell, 1993. 75(7): p. 1253-62.


Silva, A.J., R. Paylor, J.M. Wehner, and S. Tonegawa, Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science, 1992. 257(5067): p. 206-11. (
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Silva, A.J., C.F. Stevens, S. Tonegawa, and Y. Wang, Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science, 1992. 257(5067): p. 201-6. (
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Silva, A.J. and R. White, Inheritance of allelic blueprints for methylation patterns. Cell, 1988. 54(2): p. 145-52.


Silva, A.J., J.P. Johnson, and R.L. White, Characterization of a highly polymorphic region 5' to JH in the human immunoglobulin heavy chain. Nucleic Acids Res, 1987. 15(9): p. 2845-57.

Reviews/Books

Thomas Rogerson, Denise J. Cai, Adam Frank, Yoshitake Sano, Justin Shobe, Manuel F. Lopez-Aranda & Alcino J. Silva. Synaptic tagging during memory allocation. Nature Reviews Neuroscience (in press)(PDF)


Acosta MT, Bearden CE, Castellanos XF, Cutting L, Elgersma Y, Gioia G, Gutmann DH, Lee YS, Legius E, Muenke M, North K, Parada LF, Ratner N, Hunter-Schaedle K, Silva AJ. (2012). "The Learning Disabilities Network (LeaDNet): Using neurofibromatosis type 1 (NF1) as a paradigm for translational research." American Journal of Medical Genetics. Sep;158A(9):2225-32. PMID: 22821737
Gutmann DH, Parada LF, Silva AJ, Ratner N. Neurofibromatosis type 1: modeling CNS dysfunction. J Neurosci. 2012 Oct 10;32(41):14087-93. J NEUROSCI.3242-12.2012. PMID: 23055477

Silva, A.J., A career that transformed neuroscience. Brain research bulletin, 2011.

Ehninger, D. and A.J. Silva, Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders. Trends in molecular medicine, 2011. 17(2): p. 78-87.

Lee, Y.S. and A.J. Silva, Modeling hyperactivity: of mice and men. Nature Medicine, 2011. 17(5): p. 541-2. PMID: 21546967

Silva, A. J., Y. Zhou, et al. (2009). "Molecular and cellular approaches to memory allocation in neural circuits." Science 326(5951): 391-395. (
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Lee, Y-S and Silva, AJ. The molecular and cellular biology of extraordinary cognition Nat Rev Neurosci. 2009 Feb;10(2):126-40.(
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Ehninger, D., Li, W, Fox, K, Stryker, MP, and Silva, AJ. Reversing neurodevelopmental disorders in adults. Neuron 2008;60(6):950-60..(
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Won, J. and A.J. Silva, Molecular and cellular mechanisms of memory allocation in neuronetworks. Neurobiol Learn Mem, 2007.


Bontempi, B., A. Silva, and Y. Christen, Memories: Molecules and Circuits. Research and Perspectives in Neurosciences, ed. Y. Christen. 2007, Paris.


Acosta, M.T., G.A. Gioia, and A.J. Silva, Neurofibromatosis type 1: new insights into neurocognitive issues. Curr Neurol Neurosci Rep, 2006. 6(2): p. 136-43.


Murphy, G.G., N.P. Rahnama, and A.J. Silva, Investigation of age-related cognitive decline using mice as a model system: behavioral correlates. Am J Geriatr Psychiatry, 2006. 14(12): p. 1004-11.


Murphy, G.G., V. Shah, J.W. Hell, and A.J. Silva, Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates. Am J Geriatr Psychiatry, 2006. 14(12): p. 1012-21.


Nagy, V., O. Bozdagi, A. Matynia, M. Balcerzyk, P. Okulski, J. Dzwonek, R.M. Costa, A.J. Silva, L. Kaczmarek, and G.W. Huntley, Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory. J Neurosci, 2006. 26(7): p. 1923-34.


Wiltgen, B., R. Brown, L. Talton, and A. Silva, Towards a molecular and cellular cognition of remote memory. 2006, Springer.


Costa, R.M., C. Drew, and A.J. Silva, Notch to remember. Trends Neurosci, 2005. 28(8): p. 429-35.


Ehninger, D., A. Matynia, and A.J. Silva, Trafficking in emotions. Nat Neurosci, 2005. 8(5): p. 548-50.


Brown, R. and A.J. Silva, Molecular and cellular cognition; the unraveling of memory retrieval. Cell, 2004. 117(1): p. 3-4.


Wiltgen, B.J., R.A. Brown, L.E. Talton, and A.J. Silva, New circuits for old memories: the role of the neocortex in consolidation. Neuron, 2004. 44(1): p. 101-8.


Costa, R.M. and A.J. Silva, Mouse models of neurofibromatosis type I: bridging the GAP. Trends Mol Med, 2003. 9(1): p. 19-23.


Frankland, P.W., M. Ohno, E. Takahashi, A.R. Chen, R.M. Costa, S.A. Kushner, and A.J. Silva, Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory. Neuroscientist, 2003. 9(2): p. 104-9.


Silva, A., Genetic Substrates of Memory: Hippocampus, in Learning and Memory, 2nd Edition, J.H. Byrne, Editor. 2003, Macmillan Reference USA: New York. p. 171-175.


Silva, A., Memory Consolidation: Molecular and Cellular Processes, in Learning and Memory, 2nd Edition, J.H. Byrne, Editor. 2003, Macmillan Reference USA: New York. p. 366-369.


Silva, A.J., Molecular and cellular cognitive studies of the role of synaptic plasticity in memory. J Neurobiol, 2003. 54(1): p. 224-37.


Silva, A., Memory Consolidation: Molecular and Cellular Processes, in Learning and Memory, 2nd Edition, J.H. Byrne, Editor. in press, Macmillan Reference USA.


Silva, A., Genetic Substrates of Memory: Hippocampus, in Learning and Memory, 2nd Edition, J.H. Byrne, Editor. in press, Macmillan Reference USA.


Silva, A.J. and S.A. Josselyn, Cognitive neuroscience: The molecules of forgetfulness. Nature, 2002. 418(6901): p. 929-30.
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Silva, A., Memory: genetic approaches, in E-L, N.J.S.a.P.B.B. . Editor. 2001, Pergamon, Oxford. p. 9583-9586.


Silva, A.J., Genetic Approaches to Memory, in Concise Corsini Encyclopedia of Psychology and Behavioral Sciences. 2002, Pergamon: Oxford.


Costa, R.M. and A.J. Silva, Molecular and cellular mechanisms underlying the cognitive deficits associated with Neurofibromatosis type I. Journal of Child Neurology, 2002. 17.


Josselyn, S., S. Kida, P. Sandra, and A. Silva, CREB, plasticity and memory, in “Immediate Early genes and inducible transcription factors in mapping of the central nervous system function and dysfunction”, L. Kaczmarek and H. Robertson, Editors. 2002, Elsevier Science. p. 329-361.
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Matynia, A., S. Anagnostaras, and A.J. Silva, Weaving the molecular and cognitive strands of memory. Neuron, 32, 557-559, 2001.
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Silva, A.J., Y. Elgersma, and R. Costa, From genes to therapies: the role of animal models. Clinical Neuroscience Research, 2001. 1: p. 187-193.


Hamilton, S.E., S.N. Hardouin, S.G. Anagnostaras, G.G. Murphy, K.N. Richmond, A.J. Silva, E.O. Feigl, and N.M. Nathanson, Alteration of cardiovascular and neuronal function in M1 knockout mice. Life Sci, 2001. 68(22-23): p. 2489-93.


Silva, A., Genetic approaches to memory, in E-L, W.E.C.a.C.B. Nemeroff, Editor. 2001, John Wiley & Sons. p. 626-9.


Silva, A.J., Y. Elgersma, and R. Costa, Molecular and cellular mechanisms of cognitive function: implications to psychiatric disorders. Biol Psychiatry., 2000. 47(3): p. 200-9.
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Silva, A.J. and G.G. Murphy, cAMP and memory: a seminal lesson from Drosophila and Aplysia. Special issue: Highlights in Twentieth Century Neuroscience. Brain Research Bulletin, 1999.
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Pongs, O., T. Leicher, M. Berger, J. Roeper, R. Bähring, D. Wray, K.P. Giese, A.J. Silva, and J.F. Storm, Functional and molecular aspects of voltage-gated K+ channel beta subunits. Annals of the New York Academy of Sciences, 1999. 868(4-5): p. 344-55.


Elgersma, Y. and A.J. Silva, Molecular mechanisms of synaptic plasticity and memory. Curr Opin Neurobiol, 1999. 9(2): p. 209-213.


Silva, A.J., K.P. Giese, N.B. Fedorov, P.W. Frankland, and J.H. Kogan, Molecular, cellular, and neuroanatomical substrates of place learning. Neurobiol Learn Mem, 1998. 70(1-2): p. 44-61.


Silva, A.J., Y. Elgersma, E. Friedman, J. Stern, and J. Kogan, A mouse model for learning and memory defects associated with neurofibromatosis type I. Pathol Biol (Paris), 1998. 46(9): p. 697-8.


Silva, A.J., P.K. Giese, and P.W. Frankland, Identification of molecular and cellular mechanisms of learning and memory: the role of gene targeting, in The Aging Brain, E. Wang and D.S. Snyder, Editors. 1998, Academic Press: San Diego, CA. p. 68-82.


Silva, A.J. and K.P. Giese, Gene targeting: a novel window into the biology of learning and memory, in Neurobiology of learning and memory, J. Martinez and R. Kesner, Editors. 1998, Academic Press: San Diego, CA. p. 89-142.


Silva, A.J., P.W. Frankland, J.H. Kogan, E. Friedman, and N.B. Fedorov, A model for the cognitive impairments associated with NF1, in Neurofibromatosis type I (NF1): From genotype to phenotype, M. Upadhyaya and C. DN, Editors. 1998, BIOS Scientific of Oxford: Oxford.


Silva, A.J., J.H. Kogan, P.W. Frankland, and S. Kida, CREB and memory, in Annual Review of Neuroscience, Vol. 21, W.M. Cowan, Editor. 1998, Annual Reviews Inc.: Palo Alto, California, USA. p. 127-148.
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Silva, A.J., A.M. Smith, and K.P. Giese, Gene targeting and the biology of learning and memory. Annual Review of Genetics, 1997. 31(5352): p. 527-46.
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Silva, A. and etal, Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice [see comments]. Neuron, 1997. 19(4): p. 755-9.


Crawley, J.N., J.K. Belknap, A. Collins, J.C. Crabbe, W. Frankel, N. Henderson, R.J. Hitzemann, S.C. Maxson, L.L. Miner, A.J. Silva, J.M. Wehner, A. Wynshaw-Boris, and R. Paylor, Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology, 1997. 132(2): p. 107-24.


Wehner, J.M. and A. Silva, Importance of Strain Differences in Evaluations of Learning and Memory Processes in Null Mutants. Mental Retardation and Developmental Disabilities Research Reviews, 1996. 2: p. 243-248.


Fox, K., S. Glazewski, C.M. Chen, A. Silva, and X. Li, Mechanisms underlying experience-dependent potentiation and depression of vibrissae responses in barrel cortex. J Physiol Paris, 1996. 90(3-4): p. 263-9.


Silva, A.J., Genetics and learning: misconceptions and criticisms, in Gene targeting and new developments in neurobiology, S. Nakanishi , et al., Editors. 1996, Japan Scientific Societies Press: Tokyo.


Silva, A.J., N. Fedorov, J. Kogan, P. Frankland, J. Coblentz, R. Lundsten, E. Friedman, A. Smith, Y. Cho, and K.P. Giese, Genetic analysis of function and dysfunction in the central nervous system. Cold Spring Harb Symp Quant Biol, 1996. 61: p. 239-46.


Tonegawa, S., Y. Li, R.S. Erzurumlu, S. Jhaveri, C. Chen, Y. Goda, R. Paylor, A.J. Silva, J.J. Kim, J.M. Wehner, and a. et, The gene knockout technology for the analysis of learning and memory, and neural development. Prog Brain Res, 1995. 105: p. 3-14.


Silva, A.J. and K.P. Giese, Plastic genes are in! Curr Opin Neurobiol, 1994. 4(3): p. 413-20.


Silva, A.J. and P.F. Chapman, The alpha-calcium calmodulin kinase II and the plasticity of neurons, circuits and behavior. The Neurosciences, 1994. 6: p. 53-58.


Grant, S.G. and A.J. Silva, Targeting learning. Trends in Neurosciences, 1994. 17(2): p. 71-5.


Silva, A.J., Y. Wang, R. Paylor, J.M. Wehner, C.F. Stevens, and S. Tonegawa, Alpha calcium/calmodulin kinase II mutant mice: deficient long-term potentiation and impaired spatial learning. Cold Spring Harb Symp Quant Biol, 1992. 57: p. 527-39.


Silva, A.J., K. Ward, and R. White, The genetics of mosaic methylation patterns. UCLA Symposia, Nucleic Acid Methylation. Vol. 128. 1990. 395-408.


Silva, A.J. and R. White, Thesis for a Ph.D. in the Department of Human Genetics, University of Utah: The genetics of human methylation. UMI, Bell and Howell Information Company, #3058. 1989.


White, R., Y. Nakamura, C. Julier, A.J. Silva, P. O'Connell, M. Leppert, M. Lathrop, and J.-M. Lalouel, DNA Probes: Applications in Genetic and Infectious Disease and Cancer, in Current Communications in Molecular Biology, e. L.S.Lerman, Editor. 1986: Cold Spring Harbor. p. 43-47.


White, R., M. Leppert, P. O'Connel, Y. Nakamura, S. Woodward, A.J. Silva, R. Wolff, J.-M. Lalouel, and M. Lathrop,

Cold Spring Harbor Symposium. 1986. 51: p. 29-38.