Understanding and Treating Memory


autism and cognition
aging and cognition
cognitive enhancements
remote memories
plasticity and recovery
nf1 and learning
memory allocation
novel memory genes
mapping neuroscience

little research map
An example of a map summarizing information that implicates NMDA receptor function in calmodulin kinase II activation, LTP and spatial memory. For a more detailed version click here
"For an idea that does not at first seem insane, there is no hope." - Albert Einstein

The growth of the scientific literature in the last 30 years has been astronomic. The library of medicine now includes more than 20 million articles with an estimated 200 million experiments, and our own discipline (neuroscience) includes nearly two million research articles (approximately 20 million experiments.

Therefore, there is a great need to develop maps (simplified abstractions) of published information that could be used to characterize what is known and to guide research decisions. Essentially, we hope that our research maps will be to neuroscience what mathematics has been for physics: a formal language to represent research findings.

As a first step, our laboratory developed a taxonomy for experiments and a set of algorithms to generate these maps. This taxonomy allows us to classify experiments in our field into a small set of distinct categories, a critical first step in the development of simplified abstractions of research findings. The algorithms are essential for representing these experiments in causal networks (i.e., our maps).

Additionally, we have developed a free web application that helps biologists keep track and interact with causal information in research papers (

For a recent Ray Kurzweil's newsletter article on our researchmaps work click here...

Key Publications:

- Silva, AJ, Landreth, A, Bickle, J. Engineering the next revolution in neuroscience: the new science of experiment planning. Book from Oxford Press 2013
- Landreth, A, Silva, AJ, The Need for Research Maps to Navigate Published Work and Inform Experiment Planning Neuron (PDF)