new memory genes
Our laboratory has carried a genetic screen for mutants that affect memory. Unlike traditional gene screens, which use some form of mutagen, our screen takes advantage of the large number of knock-out and transgenic mice already available, but never tested for memory phenotypes.
With this novel screen, we have found several candidate genes that appear to profoundly affect memory.
We are currently studying the mechanisms modulated by these memory genes.
Matynia, A., S.G. Anagnostaras, B.J. Wiltgen, M. Lacuesta, M.S. Fanselow, and A.J. Silva, A high through-put reverse genetic screen identifies two genes involved in remote memory in mice. PLoS ONE, 2008. 3(5): p. e2121.(PDF)