Projects

<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0 height="100%"><tr> <td valign="top" width=12.5% BGCOLOR="#FFFFFF" TEXT="#080000"> <bR> </td> <td valign="top" width="100%" style=" border-top: 26px solid #FFFFFF; border-left: 63px solid #FFFFFF;border-right: 63px solid #FFFFFF;" BGCOLOR="#FFFFFF" TEXT="#080000"> <div> <TABLE BORDER="1" CELLPADDING="0" CELLSPACING="0" WIDTH="885" BORDERCOLORLIGHT="#808080" BORDERCOLORDARK="#FFFFFF" FRAME="BOX" RULES="ALL" HSPACE="0" VSPACE="0" > <tR> <tD VALIGN=TOP BGCOLOR=#DDDDDD HEIGHT= 88 ><NOBR><div> <B><IMG SRC="14d61e4a0.png" border=0 width="798" height="74" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"><IMG SRC="152953530.jpg" border=0 width="83" height="83" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></div> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#BBBBBB HEIGHT= 30 ><NOBR><div> <A HREF="index.htm" TARGET="_top" TITLE="Silvalab"><B> <IMG SRC="154761190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><B> </B><A HREF="projects.htm" TARGET="_top" TITLE="Projects "><B><IMG SRC="147e61190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="approaches.htm" TARGET="_top" TITLE="Approaches"><B><IMG SRC="147f61190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="publications.htm" TARGET="_top" TITLE="Publications"><B><IMG SRC="148061190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members"><B><IMG SRC="148161190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva"><B><IMG SRC="148261190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="awards.htm" TARGET="_top" TITLE="Awards"><B><IMG SRC="148361190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="positions.htm" TARGET="_top" TITLE="Open Positions"><B><IMG SRC="148461190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="aboutus.htm" TARGET="_top" TITLE="aboutus"><B><IMG SRC="148561190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A></div> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#6666CC HEIGHT= 20 WIDTH="881"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="20" ALIGN="bottom" WIDTH="881" HSPACE="0" VSPACE="0"></tD> </tR> </TABLE></div> <bR> <div> <TABLE BORDER="1" CELLPADDING="4" CELLSPACING="0" WIDTH="884" BORDERCOLORLIGHT="#330000" BORDERCOLORDARK="#FFFFFF" FRAME="BOX" RULES="ALL" HSPACE="0" VSPACE="0" BGCOLOR=#EEEEEE > <tR> <tD VALIGN=TOP BGCOLOR=#FFFFFF HEIGHT= 294 WIDTH="243"><div> Projects:</div> <bR> <div> <A HREF="aging.htm" TARGET="_top" TITLE="Aging and Cognition"><B>Aging and Cognition</B></A></div> <div> <A HREF="camkii.htm" TARGET="_top" TITLE="CaMKII and learning"><B>CaMKII and learning</B></A></div> <div> <A HREF="enhancements.htm" TARGET="_top" TITLE="Cognitive enhancements"><B>Cognitive enhancements</B></A></div> <div> <A HREF="cortical.htm" TARGET="_top" TITLE="Cortical memories"><B>Cortical memories</B></A></div> <div> <A HREF="recovery.htm" TARGET="_top" TITLE="Enhancing plasticity and recovery"><B>Enhancing plasticity and recovery</B></A></div> <div> <A HREF="disabilities.htm" TARGET="_top" TITLE="Learning disabilities"><B>Learning disabilities</B></A></div> <div> <A HREF="allocation.htm" TARGET="_top" TITLE="Memory allocation"><B>Memory allocation</B></A></div> <div> <A HREF="genes.htm" TARGET="_top" TITLE="Novel memory genes"><B>Novel memory genes</B></A></div> <div> <A HREF="schizophrenia.htm" TARGET="_top" TITLE="Schizophrenia"><B>Schizophrenia</B></A></div> <div> <A HREF="s2.htm" TARGET="_top" TITLE="Science of Science"><B>Science of Science</B></A></div> </tD> <tD VALIGN=TOP COLSPAN=2 BGCOLOR=#FFFFFF WIDTH="611"><div> <B>  <IMG SRC="15742da00.png" border=0 width="301" height="160" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></div> <bR> <div> Our laboratory studies mechanisms of memory and memory disorders. We use a variety of techniques and <A HREF="approaches.htm" TARGET="_top" TITLE="Approaches">approaches</A> that allow us to follow interesting questions from molecular mechanisms to the cells they affect, the circuits and neuroanatomy they modulate, all the way to behavioral studies in rodents and patients. Our field of study is <A HREF="http://www.molcellcog.org" TARGET="_top" TITLE="http://www.molcellcog.org">Molecular and Cellular Cognition</A>. </div> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=3 BGCOLOR=#CCCCE4 HEIGHT= 51 WIDTH="856"><div> Understanding cognition: what does that mean?</div> <div> see our studies on S2 <A HREF="s2.htm" TARGET="_top" TITLE="Science of Science">>></A></div> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=3 HEIGHT= 76 WIDTH="856"><bR> <div> A few highlights of our projects...</div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 499 WIDTH="243"><div>       <IMG SRC="13c5ed960.jpg" border=0 width="237" height="150" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></div> <bR> <div> Multiple memory mechanisms</div> <bR> <div> Our results implicate a variety of hippocampal and cortical mechanisms in learning and memory, including long-term potentiation, short-term plasticity, GABA inhibition and the slow afterhyperpolarization.  In the past our studies were focused on hippocampus and amygdala memory, but recently we have also studied the mechanisms responsible for <A HREF="cortical.htm" TARGET="_top" TITLE="Cortical memories">remote memory storage in the cortex</A>.  </div> </tD> <tD VALIGN=TOP WIDTH="302"><bR> <div> Memory allocation: a new question for an old problem</div> <bR> <div> <IMG SRC="13c4f88e0.png" border=0 width="248" height="142" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></div> <bR> <div> A new project in our lab is focused on how memories are <A HREF="allocation.htm" TARGET="_top" TITLE="Memory allocation">allocated in neuronetworks</A>. There is very little known about the rules that determine why one cell becomes engaged in storing a given memory while others in the same network do not. We found that CREB levels are one of the determinants of this process. Now, we are using <I>in vivo</I> imaging to study this process in behaving mice.</div> </tD> <tD VALIGN=TOP WIDTH="307"><div> <B>             </B></div> <div> <B>             <IMG SRC="13c6b6d60.jpg" border=0 width="182" height="214" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></div> <div> Beyond mechanisms: the development of treatments</div> <bR> <div> Our laboratory is developing treatments for learning and memory disorders, such as those associated with <A HREF="disabilities.htm" TARGET="_top" TITLE="Learning disabilities">learning disabilities</A>. For example, recently we have uncovered the mechanisms responsible for the learning deficits in <A HREF="nf1.htm" TARGET="_top" TITLE="Neurofibromatosis Type I">NF1</A> and <A HREF="tsc.htm" TARGET="_top" TITLE="TSC">TSC</A> and used these findings to develop treatments that we are now testing in clinical trials.</div> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=3 BGCOLOR=#FFFFFF HEIGHT= 143 WIDTH="856"><bR> <bR> <bR> <bR> <div> <B>Projects </B><B>   ·   </B><A HREF="approaches.htm" TARGET="_top" TITLE="Approaches">Approaches</A><B>   ·   </B><A HREF="publications.htm" TARGET="_top" TITLE="Publications">Publications</A><B>   ·   </B><A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members">Lab Members</A><B>   ·   </B><A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva">Alcino J. Silva</A><B>   ·   </B><A HREF="awards.htm" TARGET="_top" TITLE="Awards">Awards</A><B>   ·   </B><A HREF="pictures.htm" TARGET="_top" TITLE="Lab Pictures">Lab Pictures</A><B>   ·   </B><A HREF="positions.htm" TARGET="_top" TITLE="Open Positions">Open Positions</A><B>   ·   </B><A HREF="aboutus.htm" TARGET="_top" TITLE="aboutus">aboutus</A><B>   ·   </B><A HREF="contact_us.htm" TARGET="_top" TITLE="Contact us">Contact us</A></div> <bR> </tD> </tR> </TABLE></div> <bR> </td> </tr></table></body>