Silvalab

<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0 height="100%"><tr> <td valign="top" width=12.5% BGCOLOR="#FFFFFF" TEXT="#080000"> <bR> </td> <td valign="top" width="100%" style=" border-top: 26px solid #FFFFFF; border-left: 63px solid #FFFFFF;border-right: 63px solid #FFFFFF;" BGCOLOR="#FFFFFF" TEXT="#080000"> <div> <TABLE BORDER="1" CELLPADDING="0" CELLSPACING="0" WIDTH="888" BORDERCOLORLIGHT="#808080" BORDERCOLORDARK="#FFFFFF" FRAME="BOX" RULES="ALL" HSPACE="0" VSPACE="0" > <tR> <tD VALIGN=TOP BGCOLOR=#DDDDDD HEIGHT= 88 ><NOBR><div> <B><IMG SRC="15601e4a0.png" border=0 width="798" height="74" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"><IMG SRC="152953530.jpg" border=0 width="83" height="83" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></div> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#BBBBBB HEIGHT= 30 ><NOBR><div> <B> </B><A HREF="index.htm" TARGET="_top" TITLE="Silvalab"><B><IMG SRC="155861190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><B> </B><A HREF="projects.htm" TARGET="_top" TITLE="Projects "><B><IMG SRC="147e61190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="approaches.htm" TARGET="_top" TITLE="Approaches"><B><IMG SRC="147f61190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="publications.htm" TARGET="_top" TITLE="Publications"><B><IMG SRC="148061190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members"><B><IMG SRC="148161190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva"><B><IMG SRC="148261190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="awards.htm" TARGET="_top" TITLE="Awards"><B><IMG SRC="148361190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="positions.htm" TARGET="_top" TITLE="Open Positions"><B><IMG SRC="148461190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="aboutus.htm" TARGET="_top" TITLE="aboutus"><B><IMG SRC="148561190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A></div> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#6666CC HEIGHT= 20 WIDTH="884"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="20" ALIGN="bottom" WIDTH="884" HSPACE="0" VSPACE="0"></tD> </tR> </TABLE></div> <bR> <div> <B> <TABLE BORDER="1" CELLPADDING="4" CELLSPACING="0" WIDTH="887" BORDERCOLORLIGHT="#808080" BORDERCOLORDARK="#FFFFFF" FRAME="BOX" RULES="ALL" ALIGN="LEFT" HSPACE="0" VSPACE="0" > <tR> <tD VALIGN=TOP COLSPAN=4 BGCOLOR=#FFFFFF HEIGHT= 103 WIDTH="851"><div>  <script language="JavaScript">  </script>  </div> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=4 BGCOLOR=#6666CC HEIGHT= 14 WIDTH="851"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="14" ALIGN="bottom" WIDTH="851" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=4 BGCOLOR=#EEEEEE HEIGHT= 166 WIDTH="851"><bR> <div> <FONT SIZE="6" COLOR="#6666CC" FACE="Calibri" >Our laboratory</FONT><FONT SIZE="4" COLOR="#000000" FACE="Calibri" > </FONT><B>at UCLA is studying learning, memory and its disorders, including cognitive deficits associated with </B><A HREF="aging.htm" TARGET="_top" TITLE="Aging and Cognition"><B>aging</B></A><B>, </B><A HREF="disabilities.htm" TARGET="_top" TITLE="Learning disabilities"><B>learning disabilities</B></A><B> and </B><A HREF="schizophrenia.htm" TARGET="_top" TITLE="Schizophrenia"><B>schizophrenia</B></A><B>.  </B></div> <bR> <div> <B>Our field of study is </B><A HREF="http://www.molcellcog.org" TARGET="_top" TITLE="http://www.molcellcog.org"><B>Molecular and Cellular Cognition</B></A><B>. The goal of this field is to derive explanations of cognitive processes that integrate molecular, cellular, and behavioral mechanisms and to find treatments for cognitive disorders.</B></div> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=4 BGCOLOR=#FFFFFF HEIGHT= 338 WIDTH="851"><div> Highlights</div> <bR> <div> <B><IMG BORDER="0" SRC="Symb075c00b700f000000000.png" HEIGHT="16" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">We are searching for molecular, cellular and circuit processes that underlie the encoding, </B><A HREF="allocation.htm" TARGET="_top" TITLE="Memory allocation"><B>allocation</B></A><B>, </B><A HREF="genes.htm" TARGET="_top" TITLE="Novel memory genes"><B>storage</B></A><B> and recall of information in the brain. </B></div> <div> <B><IMG BORDER="0" SRC="Symb075c00b700f000000000.png" HEIGHT="16" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Additionally, we hope our studies of the mechanisms underlying </B><A HREF="recovery.htm" TARGET="_top" TITLE="Enhancing plasticity and recovery"><B>extraordinary cognitive function </B></A><B>may lead to general treatments for cognitive disorders.</B></div> <div> <B><IMG BORDER="0" SRC="Symb075c00b700f000000000.png" HEIGHT="16" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">We are using insights into mechanisms of memory to unravel the causes and develop treatments for cognitive deficits associated with </B><A HREF="aging.htm" TARGET="_top" TITLE="Aging and Cognition"><B>aging</B></A><B>, </B><A HREF="disabilities.htm" TARGET="_top" TITLE="Learning disabilities"><B>learning disabilities</B></A><B> and </B><A HREF="schizophrenia.htm" TARGET="_top" TITLE="Schizophrenia"><B>schizophrenia</B></A><B>.  Recently, we have shown that it is possible to reverse neurodevelopmental disorders, such as learning disabilities associated with </B><A HREF="tsc.htm" TARGET="_top" TITLE="TSC"><B>TSC</B></A><B> and </B><A HREF="nf1.htm" TARGET="_top" TITLE="Neurofibromatosis Type I"><B>NF1</B></A><B>, in adults.</B></div> <div> <B><IMG BORDER="0" SRC="Symb075c00b700f033333300.png" HEIGHT="16" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Key components of our work on </B><A HREF="cortical.htm" TARGET="_top" TITLE="Cortical memories"><B>remote memory</B></A><B> are carried out within a collaborative network, the </B><A HREF="cpm.htm" TARGET="_top" TITLE="CPM"><B>NIMH Silvio O. Conte Center for Plasticity and Memory (CPM)</B></A><B>.</B><B> Together with the labs of Michael Stryker, Kevin Fox and Joshua Trachtenberg, we are unraveling the molecular basis of cortical plasticity</B><FONT SIZE="4" COLOR="#000000" FACE="Arial" ><B> </B></FONT></div> <bR> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=4 HEIGHT= 315 ><NOBR><div> <B><IMG SRC="13f6506c0.gif" border=0 width="80" height="108" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"> <IMG SRC="13f8506b0.jpg" border=0 width="80" height="107" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"><IMG SRC="13fa50690.gif" border=0 width="80" height="105" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"><IMG SRC="13fc506a0.jpg" border=0 width="80" height="106" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"><IMG SRC="13fe506a0.jpg" border=0 width="80" height="106" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"><IMG SRC="1401506a0.jpg" border=0 width="80" height="106" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></div> <div> New papers and more:</div> <bR> <div> <B>1- New Cell paper on the role of NF1/Ras signaling on GABA release a</B><B>nd learning </B><B> (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/CuiCell2008.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>)</B></div> <div> <B>2- New Neuron review on Calmodulin kinas</B><B>e II </B><B>(</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/SoderlingNeuron Review2008.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>)</B></div> <div> <B>3- New Nature Medicine paper on the mechanism and treatment for cognitive deficits in TSC (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/DanNM2008.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>)</B></div> <div> <B>4- New JAMA paper with a promising treatment for NF1  (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/YpeJAMA2008.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>)</B></div> <div> <B>5- New Plos paper on novel approach to screen for remote memory mutants (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/DanNM2008.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>)</B></div> <div> <B>6- New JP paper on the science of research (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/silvajp2008.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>)</B></div> <bR> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=4 HEIGHT= 107 WIDTH="851"><bR> <bR> <div> <A HREF="projects.htm" TARGET="_top" TITLE="Projects ">Projects </A>   ·   <A HREF="approaches.htm" TARGET="_top" TITLE="Approaches">Approaches</A>   ·   <A HREF="publications.htm" TARGET="_top" TITLE="Publications">Publications</A>   ·   <A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members">Lab Members</A>   ·   <A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva">Alcino J. Silva</A>   ·   <A HREF="awards.htm" TARGET="_top" TITLE="Awards">Awards</A>   ·   <A HREF="pictures.htm" TARGET="_top" TITLE="Lab Pictures">Lab Pictures</A>   ·   <A HREF="positions.htm" TARGET="_top" TITLE="Open Positions">Open Positions</A>   ·   <A HREF="aboutus.htm" TARGET="_top" TITLE="aboutus">aboutus</A>   ·   <A HREF="contact_us.htm" TARGET="_top" TITLE="Contact us">Contact us</A></div> <bR> <div> web site by alcino silva</div> </tD> </tR> </TABLE></B></div> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> </td> </tr></table></body>