CREB And Memory

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For example, our studies showed that mice with CREB mutations showed normal short-term, but abnormal long-term memory for a variety of cognitive tasks.  </B></div> <bR> <div> <B>To better define the role of CREB in distinct memory processes, we developed a temporal and brain-specific system using a dominant negative CREB (CREB</B><B>S133A</B><B>) fused with a tamoxifen-dependent mutant of an estrogen receptor ligand-binding domain.  With this inducible transgenic system, we were able to effectively repress CREB function in 6 hr. and completely reverse this effect in less than 24 hr. We found that CREB is crucial for the consolidation, but not for the encoding, storage or retrieval of conditioned memory.  The process of remembering is thought to reactivate memory representations in the brain. Our studies show that disrupting CREB function during remembering disrupts the recalled memories, suggesting that remembering triggers a second wave of memory consolidation (reconsolidation).  </B><B>These studies may have an important clinical implication: the ability to interfere with memory may be used to treat the devastating emotional impact of traumatic memories.  For a recent NIH review of this work </B><A HREF="http://www.ncrr.nih.gov/newspub/jul02rpt/stories2.asp" TARGET="_top" TITLE="http://www.ncrr.nih.gov/newspub/jul02rpt"><B>click her</B></A><B>e</B></div> <bR> <div> <B>Recently, we have also shown that CREB has a key role in determining where memories are stored in neuronetworks. Neurons with higher levels of CREB become memory attractors, while those with low levels are less likely to participate in storing a given memory. For more information on this work, click here</B></div> </td> </tr></table></body>