CPM Projects

<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0><tr> <td valign="top" colspan=2 height=190 BGCOLOR="#111111" TEXT="#F7F7FF" bgproperties="fixed" background="116300c20dyxtip.jpg"> <bR> <bR> <bR> <bR> <div> <B>  </B><FONT SIZE="4" COLOR="#FFFFCC" FACE="Arial" ><B>                 </B></FONT></div> <div> <B>     </B></div> <div> </div> </td> </tr><tr> <td valign="top" width=248 style="border-right: 2px solid #777777;" BGCOLOR="#EEEEEE" TEXT="#080000"> <div> <B>CPM Projects</B></div> <div> <A HREF="cpmcores.htm" TARGET="_top" TITLE="CPM Cores"><B>CPM Cores</B></A></div> <div> <A HREF="cpmfunds.htm" TARGET="_top" TITLE="CPM Funding"><B>CPM Funding</B></A></div> <div> <A HREF="cpmpubs.htm" TARGET="_top" TITLE="CPM Publications"><B>CPM Publications</B></A></div> <div> <A HREF="cpmmeeetings.htm" TARGET="_top" TITLE="CPM Meetings"><B>CPM Meetings</B></A></div> <div> <A HREF="cpmmutants.htm" TARGET="_top" TITLE="Novel Mutants"><B>Novel Mutants</B></A></div> <div> <A HREF="board.htm" TARGET="_top" TITLE="Advisory Board"><B>Advisory Board</B></A></div> <bR> <bR> <div> <A HREF="cpm.htm" TARGET="_top" TITLE="CPM"><B>CPM HOME</B></A></div> <bR> <div> <A HREF="index.htm" TARGET="_top" TITLE="Silvalab"><B>Silvalab Home</B></A></div> <bR> <bR> </td> <td valign="top" height=290 width="100%" BGCOLOR="#FFFFFF" TEXT="#080000"> <bR> <bR> <bR> <div> <B>CPM Projects</B></div> <bR> <div> <B>Project 1 (PI: Alcino Silva)</B></div> <div> <B>1- To identify genes specifically required for remote (but not  recent...) memory for contextual conditioning. </B></div> <div> <B>2- To derive region and temporally specific mutations for genes that affect remote memory for contextual conditioning. </B></div> <div> <B>3- To uncover cortical molecular mechanisms underlying the turnover and stability of spines in  anterior cingulate and prefrontal cortex. </B></div> <bR> <div> <B>Project 2 (PI: Kevin Fox)</B></div> <div> <B>1. To determine whether experience-dependent plasticity (EDP) is normal in the remote memory mutants. </B></div> <div> <B>2. To ascertain whether the anatomical and receptive field development of the barrel cortex is normal in the remote memory mutants. </B></div> <div> <B>3. To test whether spine and bouton stability, turnover and plasticity are normal in whisker deprived and undeprived animals. </B></div> <div> <B>4. To determine whether cortical plasticity/remote memory mutations affect excitatory synaptic transmission and spike-timing dependent plasticity. </B></div> <bR> <div> <B>Project 3 (PI: Michael Stryker)</B></div> <div> <B>1.  To identify genes required for ocular-dominance plasticity.  </B></div> <div> <B>2. To determine whether plasticity mutations selected in our screen cause deficits in receptive field properties and/or map organization. </B></div> <div> <B>3. To test whether plasticity mutations selected in our screen cause deficits in the stability and turnover of spines and boutons in vivo under baseline conditions and after a plasticity-inducing stimulus.  </B></div> <div> <B>4. To determine whether plasticity mutations cause deficits in synaptic transmission during the critical period. </B></div> <bR> <bR> <div> <B>Collaborative Framework</B></div> <div> <B><IMG SRC="11ae1a9c0.jpg" border=0 width="1050" height="668" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></div> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> </td> </tr></table></body>