Cortical memories

<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0 height="100%"><tr> <td valign="top" width=12.5% BGCOLOR="#FFFFFF" TEXT="#080000"> <bR> </td> <td valign="top" width="100%" style=" border-top: 26px solid #FFFFFF; border-left: 63px solid #FFFFFF;border-right: 63px solid #FFFFFF;" BGCOLOR="#FFFFFF" TEXT="#080000"> <bR> <div> <TABLE BORDER="1" CELLPADDING="0" CELLSPACING="0" WIDTH="785" BORDERCOLORLIGHT="#808080" BORDERCOLORDARK="#FFFFFF" FRAME="BOX" RULES="ALL" HSPACE="0" VSPACE="0" > <tR> <tD VALIGN=TOP BGCOLOR=#DDDDDD HEIGHT= 76 ><NOBR><div> <A HREF="index.htm" TARGET="_top" TITLE="Silvalab"><B><IMG SRC="14860c470.png" border=0 width="780" height="71" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A></div> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#BBBBBB HEIGHT= 30 ><NOBR><div> <B> </B><A HREF="projects.htm" TARGET="_top" TITLE="Projects "><B><IMG SRC="147e61190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="approaches.htm" TARGET="_top" TITLE="Approaches"><B><IMG SRC="147f61190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="publications.htm" TARGET="_top" TITLE="Publications"><B><IMG SRC="148061190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members"><B><IMG SRC="148161190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva"><B><IMG SRC="148261190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="funding.htm" TARGET="_top" TITLE="Awards"><B><IMG SRC="148361190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="positions.htm" TARGET="_top" TITLE="Open Positions"><B><IMG SRC="148461190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="aboutus.htm" TARGET="_top" TITLE="aboutus"><B><IMG SRC="148561190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A></div> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#6666CC HEIGHT= 20 WIDTH="781"><div>        <A HREF="index.htm" TARGET="_top" TITLE="Silvalab"><B>Home</B></A></div> </tD> </tR> </TABLE></div> <div> <TABLE BORDER="1" CELLPADDING="4" CELLSPACING="0" WIDTH="781" BORDERCOLORLIGHT="#330000" BORDERCOLORDARK="#FFFFFF" FRAME="BOX" RULES="ALL" HSPACE="0" VSPACE="0" BGCOLOR=#EEEEEE > <tR> <tD VALIGN=TOP BGCOLOR=#FFFFFF HEIGHT= 650 WIDTH="769"><div> <IMG SRC="1073f9c00.jpg" border=0 width="505" height="192" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></div> <bR> <div> Cortical plasticity and memory</div> <bR> <div> <B>Our laboratory has started a new project focused on unraveling the molecular, cellular and systems mechanisms responsible for memory storage in neocortcal networks. Although there is very little known about how our oldest memories are stored, our laboratory has already demonstrated the involvement of specific molecular processes and physiological mechanisms in this fascinating phase of memory. We have also developed a genetic screen that yielded 2 new genes that have a critical role in remote memory, and we are currently using </B><A HREF="approaches339.htm" TARGET="_top" TITLE="in vivo Imaging"><B>in vivo 2-photon imaging</B></A><B> to unravel the cortical processes modulated by these genes.</B></div> <bR> <div> <B>Importantly, we have a long standing collaboration with the laboratories of Joshua Trachetenberg, Kevin Fox, and Michael Stryker on molecular and cellular mechanisms involved in cortical pasticity. Our results suggest that these mechanisms have a central role in remote memory. These studies are continuing under the auspices of our new </B><A HREF="cpm.htm" TARGET="_top" TITLE="CPM"><B>NIMH Conte Center.</B></A></div> <bR> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 184 WIDTH="769"><bR> <div> For descriptions of our other projects click on one of the links below...</div> <bR> <div> <A HREF="aging.htm" TARGET="_top" TITLE="Aging and Cognition">Aging and Cognition</A>   ·   <A HREF="camkii.htm" TARGET="_top" TITLE="CaMKII and Learning">CaMKII and Learning</A>   ·   <A HREF="enhancements.htm" TARGET="_top" TITLE="Cognitive enhancements">Cognitive enhancements</A>   ·   <B>Cortical memories</B>   ·   <A HREF="recovery.htm" TARGET="_top" TITLE="Enhancing plasticity and recovery">Enhancing plasticity and recovery</A>   ·   <A HREF="ld.htm" TARGET="_top" TITLE="Learning disabilities">Learning disabilities</A>   ·   <A HREF="allocation.htm" TARGET="_top" TITLE="Memory Allocation">Memory Allocation</A>   ·   <A HREF="genes.htm" TARGET="_top" TITLE="Novel memory genes">Novel memory genes</A>   ·   <A HREF="schizophrenia.htm" TARGET="_top" TITLE="Schizophrenia">Schizophrenia</A>   ·   <A HREF="s2.htm" TARGET="_top" TITLE="Science of Science">Science of Science</A></div> </tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#FFFFFF HEIGHT= 162 WIDTH="769"><bR> <bR> <bR> <bR> <div> <A HREF="projects.htm" TARGET="_top" TITLE="Projects ">Projects </A>   ·   <A HREF="approaches.htm" TARGET="_top" TITLE="Approaches">Approaches</A>   ·   <A HREF="publications.htm" TARGET="_top" TITLE="Publications">Publications</A>   ·   <A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members">Lab Members</A>   ·   <A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva">Alcino J. Silva</A>   ·   <A HREF="funding.htm" TARGET="_top" TITLE="Awards">Awards</A>   ·   <A HREF="pictures.htm" TARGET="_top" TITLE="Lab Pictures">Lab Pictures</A>   ·   <A HREF="positions.htm" TARGET="_top" TITLE="Open Positions">Open Positions</A>   ·   <A HREF="aboutus.htm" TARGET="_top" TITLE="aboutus">aboutus</A>   ·   <A HREF="contact_us.htm" TARGET="_top" TITLE="Contact us">Contact us</A></div> <bR> </tD> </tR> </TABLE></div> <bR> <div> <TABLE BORDER="0" CELLPADDING="2" CELLSPACING="1" WIDTH="532" BORDERCOLORLIGHT="#C0C0C0" BORDERCOLORDARK="#808080" FRAME="BOX" RULES="ALL" HSPACE="0" VSPACE="0" > <tR> <tD VALIGN=TOP HEIGHT= 544 WIDTH="526"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="544" ALIGN="bottom" WIDTH="526" HSPACE="0" VSPACE="0"></tD> </tR> </TABLE></div> <bR> <div> <B> </B></div> <bR> <bR> </td> </tr></table></body>