Single unit studies
To understand learning and memory it will be critical to unravel the rules of how information is processed in neuronal circuits. Thus, our laboratory has used stereotrodes and tetrodes to record the activity of brain cells/circuits in behaving mice. For example, we have studied the properties of hippocampal cells that fire in specific places in the animal's environment (place cells). The study of several different mutants have shown that the loss of long lasting synaptic changes do not disrupt the formation of place fields, but interfere with their stability. We are also using single unit recordings to study the firing properties of neurons in learning brains.
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