approaches
Our laboratory uses a number of approaches to study learning and memory at multiple levels of analyses. Essentially, we use the best possible techniques we can to address the problems we are studying.
Molecular manipulations
Although many of our studies include mice with defined mutations, we have also taken advantage of a number of other strategies to manipulate molecular function in the brain, including pharmacology and gene transfer with viral vectors.
Neurons/Systems
We are using time-lapse two-photon confocal imaging in vivo and optogenetics to define the cellular neurosystems involved in memory. We also use a number of electrophysiological approaches to study the cell biology of learning and memory, and neuroanatomic lesions to assess the role of specific brain regions.
Behavior/Cognition
Most of our studies start with extensive behavioral analyses. For this purpose our laboratory uses a number of tests that allow us to evaluate a wide range of rodent behaviors. We have also initiated cognitive neuroscience studies with patients using techniques such as brain imaging