Approaches

<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0><tr> <td valign="top" colspan=2 height=175 BGCOLOR="#333366" TEXT="#080000" bgproperties="fixed" background="12b400af0dkcfsz.jpg"> <bR> <div> <A HREF="index.htm" TARGET="_top" TITLE="Silvalab"><U><B>Silvalab</B></U></A></div> <bR> <bR> <bR> <bR> <bR> <div>    </div> <div> <B> </B><A HREF="index.htm" TARGET="_top" TITLE="Silvalab"><U><B>HOME</B></U></A><B>          </B><A HREF="projects.htm" TARGET="_top" TITLE="Projects"><U><B>Projects</B></U></A><B>   |   </B><B>Approaches</B><B>   |   </B><A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members"><U><B>Lab Members</B></U></A><B>   |   </B><A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva"><U><B>Alcino J. Silva</B></U></A><B>   |   </B><A HREF="publications.htm" TARGET="_top" TITLE="Publications"><U><B>Publications</B></U></A><B>   |   </B><A HREF="funding.htm" TARGET="_top" TITLE="Acknowledgments"><U><B>Acknowledgments</B></U></A><B>   |   </B><A HREF="pictures.htm" TARGET="_top" TITLE="Lab Pictures"><U><B>Lab Pictures</B></U></A><B>   |   </B><A HREF="info.htm" TARGET="_top" TITLE="Information"><U><B>Information</B></U></A><B>   |   </B><A HREF="positions.htm" TARGET="_top" TITLE="Open Positions"><U><B>Open Positions</B></U></A><B>   |   </B><A HREF="contact_us.htm" TARGET="_top" TITLE="Contact us"><U><B>Contact us</B></U></A></div> <div> <B>        </B></div> <div>                        </div> <bR> <div> </div> </td> </tr><tr> <td valign="top" width=150 BGCOLOR="#FFFFFF" TEXT="#080000"> <bR> <div> <A HREF="approaches64.htm" TARGET="_top" TITLE="Molecular Genetics"><U><B>Molecular Genetics</B></U></A></div> <div> <A HREF="approaches69.htm" TARGET="_top" TITLE="PRISM"><U><B>PRISM</B></U></A></div> <div> <A HREF="electrophysiology.htm" TARGET="_top" TITLE="Electrophysiology"><U><B>Electrophysiology</B></U></A></div> <div> <A HREF="approaches67.htm" TARGET="_top" TITLE="Brain lesions"><U><B>Brain lesions</B></U></A></div> <div> <A HREF="approaches339.htm" TARGET="_top" TITLE="in vivo Imaging"><U><B>in vivo Imaging</B></U></A></div> <div> <A HREF="behavior.htm" TARGET="_top" TITLE="Behavioral Analyses"><U><B>Behavioral Analyses</B></U></A></div> <div> <A HREF="micetomen.htm" TARGET="_top" TITLE="Bridging Mice and Men"><U><B>Bridging Mice and Men</B></U></A></div> <bR> </td> <td valign="top" height=305 BGCOLOR="#FFFFFF" TEXT="#080000"> <div> <IMG SRC="121015330.png" border=0 width="277" height="51" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></div> <div> <B>Our laboratory uses a number of approaches to study learning and memory.  Although many of our studies include mice with defined </B><A HREF="approaches64.htm" TARGET="_top" TITLE="Molecular Genetics"><U><B>mutations,</B></U></A><B> we have also taken advantage of a number of other strategies to manipulate molecular function in the brain, including </B><A HREF="approaches69.htm" TARGET="_top" TITLE="PRISM"><U><B>pharmacology</B></U></A><B> and gene transfer with viral vectors. We use </B><A HREF="electrophysiology.htm" TARGET="_top" TITLE="Electrophysiology"><U><B>slice electrophysiology</B></U></A><B> to study the cell biology of learning and memory, and </B><A HREF="approaches67.htm" TARGET="_top" TITLE="Brain lesions"><U><B>neuroanatomic lesions</B></U></A><B> to assess the role of specific brain regions. We also use </B><A HREF="approaches339.htm" TARGET="_top" TITLE="in vivo Imaging"><U><B>time-lapse two-photon confocal imaging </B></U></A><A HREF="approaches339.htm" TARGET="_top" TITLE="in vivo Imaging"><U><I><B>in vivo</B></I></U></A><B> to define cellular neurosystems and dendritic structural changes during remote memory. Most of our studies start with extensive </B><A HREF="behavior.htm" TARGET="_top" TITLE="Behavioral Analyses"><U><B>behavioral analysis</B></U></A><B>. For this purpose our laboratory uses a number of tests that allow us to evaluate a wide range of mouse behaviors. Currently, we are also carrying out parallel studies in </B><A HREF="micetomen.htm" TARGET="_top" TITLE="Bridging Mice and Men"><U><B>humans</B></U></A><B>.</B></div> <bR> <div> <B>For more info on the individual approaches we use, please click on the topics below:</B></div> <bR> <div> <A HREF="approaches64.htm" TARGET="_top" TITLE="Molecular Genetics"><U><B>Molecular Genetics</B></U></A></div> <div> <A HREF="approaches69.htm" TARGET="_top" TITLE="PRISM"><U><B>PRISM</B></U></A></div> <div> <A HREF="electrophysiology.htm" TARGET="_top" TITLE="Electrophysiology"><U><B>Electrophysiology</B></U></A></div> <div> <A HREF="approaches67.htm" TARGET="_top" TITLE="Brain lesions"><U><B>Brain lesions</B></U></A></div> <div> <A HREF="approaches339.htm" TARGET="_top" TITLE="in vivo Imaging"><U><B>in vivo Imaging</B></U></A></div> <div> <A HREF="behavior.htm" TARGET="_top" TITLE="Behavioral Analyses"><U><B>Behavioral Analyses</B></U></A></div> <div> <A HREF="micetomen.htm" TARGET="_top" TITLE="Bridging Mice and Men"><U><B>Bridging Mice and Men</B></U></A></div> <bR> <bR> <div> <B>There is a society for laboratories like ours that are interested in a molecular to behavioral, multiple-level analysis of cognition. For information concerning the </B><A HREF="http://www.molcellcog.org" TARGET="_top" TITLE="http://www.molcellcog.org"><U><B>Molecular and Cellular Cognition Society click here</B></U></A><B>.  </B></div> <bR> </td> </tr></table></body>