Project 1 (PI: Alcino Silva)
1- To identify novel genes required for memory for contextual conditioning.
2- To uncover cellular structural mechanisms underlying memory.
3- To determine the mechanisms of memory allocation.
Project 2 (PI: Kevin Fox)
1. To determine whether experience-dependent plasticity (EDP) is normal in memory mutants identified in our screen.
2. To ascertain whether the anatomical and receptive field development of the barrel cortex is normal in memory mutants identified in our screen.
3. To test whether spine and bouton stability, turnover and plasticity are normal in whisker deprived and undeprived animals.
4. To determine whether cortical plasticity memory mutations identified in our screen affect excitatory synaptic transmission and spike-timing dependent plasticity.
Project 3 (PI: Michael Stryker)
1. To identify genes required for ocular-dominance plasticity.
2. To determine whether plasticity mutations selected in our screen cause deficits in receptive field properties and/or map organization.
3. To test whether plasticity mutations selected in our screen cause deficits in the stability and turnover of spines and boutons in vivo under baseline conditions and after a plasticity-inducing stimulus.
4. To determine whether plasticity mutations cause deficits in synaptic transmission during the critical period.
The key goal of our center is to uncover novel mechanisms of cortical sensory plasticity and memory storage by taking advantage of state-of-the-art genetic and imaging tools that are allowing us to bridge the fields of memory research and sensory plasticty